-Comfortis kills fleas before they can lay eggs

The same regimen for Comfortis can be applied in administering Trifexis for dogs.
Dogs who are taking the flea preventive drug Comfortis (spinosad) at the same time they are being given high dosages of the drug ivermectin, such as those used in the treatment of demodetic mange, are at risk of ivermectin toxicity.

The maker of the drug, Eli Lilly's companion animal health division, does not believe that there is any risk to using the regular heartworm-prevention dose of ivermectin with Comfortis; the daily dosages used to treat some stubborn cases of demodetic mange are as much as 100 times the monthly dosage used to prevent heartworm infection. In an informational release, the company cited a supporting field study that involved hundreds of dogs ():

The administration of Comfortis and approved canine formulations of ivermectin at doses labeled for heartworm prevention has been tested and shown to be safe, including in a North American field trial involving over 450 dogs that were required to be on monthly heartworm prevention throughout the three-month study. Laboratory work has found that, even at doses of 5 times the monthly dose of spinosad combined with 10 times the monthly dose of milbemycin oxime in ivermectin-sensitive collies, there were no signs of neurotoxicity (Sherman et al., publication pending).

The FDA Center for Veterinary Medicine is that the two drugs not be prescribed at the same time.

If necessary, you can administer Comfortis like you would other tablet medications.

Spinosad is a PgP substrate, which means it could potentially interact with other PgP substrates such as doxorubicin and digoxin. There is also the possibility for an interaction between Comfortis and ivermectin. When ivermectin is used in conjunction with spinosad, and at the higher doses often used for the treatment of mange, there is a significantly increased risk of negative side effects. Never give spinosad to dogs who have previously suffered bad reactions to it.
Fleas can cause discomfort and disease. If Comfortus worked well for you, I would keep using it.P.S. My older dog did not want the comfortis. I had to break it down. Canine Intuitiveness?Do not use the dosing schedule below when administering COMFORTIS to dogs, as it can result in overdosage.
Comfortis is a useful insecticide based on spinosad, a substance derived from soil microbes. While studies have shown the incidence of severe reactions to be low, there are still some reports of serious side effects from owners. Existing medical conditions and mixing the substance with other drugs or supplements can increase the chances of a bad reaction. Known contraindications and interactions are listed below.
An ounce of prevention is better than a pound of cure and this philosophy is also true for fleas. Comfortis can be taken at any time of the year, but it is best to use it a month before flea season. In warmer areas or climates, Comfortis must be administered year-round. It can be taken with or without food. For maximum results, dogs must eat a meal before taking a tablet.Comfortis orange are for small dogs and puppies weighing 10 to 20 lbs. Comfortis is an oral flea medication used to kill fleas and stop flea infestation fast. It is the first FDA approved flea treatment on the market for dogs where dogs can take it orally. The main ingredient is spinosad which is used to stop the fleas egg cycle and kill off fleas.Having fleas can be uncomfortable for your pet. In extreme cases, it can even be fatal. It is important for any responsible pet owner to seek the right treatment for fleas as soon as they are detected. There are also products that are formulated to prevent them from infesting your pets. Two of the most popular products in the market today are Comfortis and Nexgard. Check them out in this review.So far, I’ve checked my dog and he has no fleas crawling on him anymore. The fleas seem to have to gone away. No more itching for both him and my family!! Comfortis is pretty amazing and it comes in for all different sized dogs. So check it out. I am going to post a link below to get your supply of comfortis today so you and your dog can be itch free.It appears that the reported adverse responses to Comfortis such as vomiting with blood, diarrhea with blood, mobility condition, and neurological conditions are all just consequences of irresponsible judgment. Some people can go as far as saying that their pets have died without showing any evidence – no pictures of remains, no hospitalization images, no owner faces, etc. This calls for more research and strict implementation of laws covering proper use of the internet.